A pretty good read. I wouldn't say it's particularly in-depth, and they do generalize quite a bit (i.e, just because something worked for them doesn't make it universally true). That said, it's a quick read, broken up into bite-sized chunks (blog posts grouped into chapters, basically).
I can't say it has anything I disagree with -- the advice is solid enough (IMHO). But I do think that it doesn't dive deep enough to be used as a primary reference when trying to start a new business (or even an internal project). Reading this immediately after the Lean Startup book makes the contrast in depth quite stark.